Youth suicide is a significant public health concern in the USA, ranking as the second leading cause of death for youth and young adults. Schools are increasingly being called upon to be involved in suicide prevention efforts, ideally in partnership with parents and caregivers; however, few school-based suicide prevention interventions incorporate families into their strategies. The current study evaluates the feasibility, acceptability, and short-term outcomes of Asking is Caring (AiC), a mental health promotion and suicide prevention program delivered by families to families in coordination with schools. Results from this initial pilot with 191 parent/caregiver training recipients show that parents serving as AiC trainers have significant credibility and, ratings of the AiC curriculum and collateral materials were high. With respect to short-term outcomes, AiC participants reported improved knowledge, self-efficacy, attitudes, and behaviors related to youth suicide prevention. Changes in self-reported use of empathic listening with youth and maintaining suicide resources in phone contacts were particularly robust and sustained beyond the immediate post-training survey, as were perceived confidence and comfort in supporting youth. Safe firearm and medication storage practices also improved; however, only 29% of trainees reported secure storage of medications at follow-up, highlighting the need for additional and/or more intensive strategies to reduce youths’ access to lethal means. Overall, results indicate AiC holds promise as a feasible and acceptable suicide prevention strategy for use in collaboration with schools.